Bromodomains: are readers right for epigenetic therapy?
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ABSTRACT:
SUBMITTER: Conway SJ
PROVIDER: S-EPMC4025779 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
Bromodomains: are readers right for epigenetic therapy?
ACS medicinal chemistry letters 20120809 9
There is intense interest in the development of small molecule inhibitors of the acetyl-lysine-reading bromodomain protein module. These inhibitors represent a way of interfering therapeutically in epigenetic processes, and there are currently two bromodomain inhibitors in clinical trials. The success of these compounds rests on safety aspects of epigenetic target modulation being addressed. ...[more]
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