Heteroaromatic Moieties in the Sphingosine Backbone of ?-Galactosylceramides for Noncovalent Interactions with CD1d.
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ABSTRACT:
SUBMITTER: Kim Y
PROVIDER: S-EPMC4025800 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Heteroaromatic Moieties in the Sphingosine Backbone of α-Galactosylceramides for Noncovalent Interactions with CD1d.
Kim Yongju Y Kim Jonghoon J Oh Keunhee K Lee Dong-Sup DS Park Seung Bum SB
ACS medicinal chemistry letters 20120110 2
A series of α-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of α-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines. ...[more]
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