Ontology highlight
ABSTRACT:
SUBMITTER: Vusurovic J
PROVIDER: S-EPMC6335609 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Vušurović Jovana J Breuker Kathrin K
Analytical chemistry 20190107 2
Interactions of ribonucleic acids (RNA) with basic ligands such as proteins or aminoglycosides play a key role in fundamental biological processes. Native top-down mass spectrometry (MS) has recently been extended to binding site mapping of RNA-ligand interactions by collisionally activated dissociation, without the need for laborious sample preparation procedures. The technique relies on the preservation of noncovalent interactions at energies that are sufficiently high to cause RNA backbone cl ...[more]