Ontology highlight
ABSTRACT:
SUBMITTER: Feil SC
PROVIDER: S-EPMC4025830 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Feil Susanne C SC Hamilton Stephanie S Krippner Guy Y GY Lin Bo B Luttick Angela A McConnell Darryl B DB Nearn Roland R Parker Michael W MW Ryan Jane J Stanislawski Pauline C PC Tucker Simon P SP Watson Keith G KG Morton Craig J CJ
ACS medicinal chemistry letters 20120213 4
Respiratory infections caused by human rhinovirus are responsible for severe exacerbations of underlying clinical conditions such as asthma in addition to their economic cost in terms of lost working days due to illness. While several antiviral compounds for treating rhinoviral infections have been discovered, none have succeeded, to date, in reaching approval for clinical use. We have developed a potent, orally available rhinovirus inhibitor 6 that has progressed through early clinical trials. ...[more]