Ontology highlight
ABSTRACT:
SUBMITTER: Rafalski VA
PROVIDER: S-EPMC4026158 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Rafalski Victoria A VA Ho Peggy P PP Brett Jamie O JO Ucar Duygu D Dugas Jason C JC Pollina Elizabeth A EA Chow Lionel M L LM Ibrahim Adiljan A Baker Suzanne J SJ Barres Ben A BA Steinman Lawrence L Brunet Anne A
Nature cell biology 20130505 6
Oligodendrocytes-the myelin-forming cells of the central nervous system-can be regenerated during adulthood. In adults, new oligodendrocytes originate from oligodendrocyte progenitor cells (OPCs), but also from neural stem cells (NSCs). Although several factors supporting oligodendrocyte production have been characterized, the mechanisms underlying the generation of adult oligodendrocytes are largely unknown. Here we show that genetic inactivation of SIRT1, a protein deacetylase implicated in en ...[more]