Ontology highlight
ABSTRACT:
SUBMITTER: Demin O
PROVIDER: S-EPMC4026633 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Demin O O Karelina T T Svetlichniy D D Metelkin E E Speshilov G G Demin O O Fairman D D van der Graaf P H PH Agoram B M BM
CPT: pharmacometrics & systems pharmacology 20130911
Zileuton, a 5-lipoxygenase (5LO) inhibitor, displays complex pharmaokinetic (PK)-pharmacodynamic (PD) behavior. Available clinical data indicate a lack of dose-bronchodilatory response during initial treatment, with a dose response developing after ~1-2 weeks. We developed a quantitative systems pharmacology (QSP) model to understand the mechanism behind this phenomenon. The model described the release, maturation, and trafficking of eosinophils into the airways, leukotriene synthesis by the 5LO ...[more]