Ontology highlight
ABSTRACT:
SUBMITTER: Respondek T
PROVIDER: S-EPMC4027032 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Respondek Tomasz T Garner Robert N RN Herroon Mackenzie K MK Podgorski Izabela I Turro Claudia C Kodanko Jeremy J JJ
Journal of the American Chemical Society 20111012 43
A novel method for caging protease inhibitors is described. The complex [Ru(II)(bpy)(2)(1)(2)](PF(6))(2) (2) was prepared from the nitrile-based peptidomimetic inhibitor Ac-Phe-NHCH(2)CN (1). (1)H NMR, UV-vis, and IR spectroscopic and mass spectrometric data confirmed that 2 equiv of inhibitor 1 bind to Ru(II) through the nitrile functional group. Complex 2 shows excellent stability in aqueous solution in the dark and fast release of 1 upon irradiation with visible light. As a result of binding ...[more]