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[Ru(bpy)2(5-cyanouracil)2]2+ as a potential light-activated dual-action therapeutic agent.

ABSTRACT: The cation cis-[Ru(bpy)(2)(5CNU)(2)](2+) (bpy = 2,2'-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active 5CNU and generating [Ru(bpy)(2)(H(2)O)(2)](2+). The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therapeutic agents from a single molecule.

SUBMITTER: Garner RN

PROVIDER: S-EPMC4556276 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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[Ru(bpy)2(5-cyanouracil)2]2+ as a potential light-activated dual-action therapeutic agent.

Garner Robert N RN Gallucci Judith C JC Dunbar Kim R KR Turro Claudia C

Inorganic chemistry 20110831 19

The cation cis-[Ru(bpy)(2)(5CNU)(2)](2+) (bpy = 2,2'-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active 5CNU and generating [Ru(bpy)(2)(H(2)O)(2)](2+). The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therape ...[more]

PMID: 21879748

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