Ontology highlight
ABSTRACT:
SUBMITTER: Nesi G
PROVIDER: S-EPMC4027130 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20131018 12
This study was aimed at investigating the antitumor activity of novel 2-oxindole derivatives against a well-characterized human nonsmall cell lung cancer (NSCLC) cell line. Test compounds produced an antiproliferative activity in the low micromolar/submicromolar range of concentrations and significantly induced typical apoptotic morphology with cell shrinkage, nuclear condensation and fragmentation, and rupture of cells into debris in a relatively low percentage of A549 cells. Cell cycle arrest ...[more]