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Synthesis and Biological Evaluation of Phaeosphaeride A Derivatives as Antitumor Agents.

ABSTRACT: New derivatives of phaeosphaeride A (PPA) were synthesized and characterized. Anti-tumor activity studies were carried out on the HCT-116, PC3, MCF-7, A549, ?562, NCI-?929, Jurkat, THP-1, RPMI8228 tumor cell lines, and on the HEF cell line. All of the compounds synthesized were found to have better efficacy than PPA towards the tumor cell lines mentioned. Compound 6 was potent against six cancer cell lines, HCT-116, PC-3, K562, NCI-H929, Jurkat, and RPMI8226, showing a 47, 13.5, 16, 4, 1.5, and 7-fold increase in anticancer activity comparative to those of etoposide, respectively. Compound 1 possessed selectivity toward the NCI-H929 cell line (IC50 = 1.35 ± 0.69 ?M), while product 7 was selective against three cancer cell lines, HCT-116, MCF-7, and NCI-H929, each having IC50 values of 1.65 ?M, 1.80 ?M and 2.00 ?M, respectively.

SUBMITTER: Abzianidze V

PROVIDER: S-EPMC6278656 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Synthesis and Biological Evaluation of Phaeosphaeride A Derivatives as Antitumor Agents.

Abzianidze Victoria V Beltyukov Petr P Zakharenkova Sofya S Moiseeva Natalia N Mejia Jennifer J Holder Alvin A Trishin Yuri Y Berestetskiy Alexander A Kuznetsov Victor V

Molecules (Basel, Switzerland) 20181121 11

New derivatives of phaeosphaeride A (PPA) were synthesized and characterized. Anti-tumor activity studies were carried out on the HCT-116, PC3, MCF-7, A549, К562, NCI-Н929, Jurkat, THP-1, RPMI8228 tumor cell lines, and on the HEF cell line. All of the compounds synthesized were found to have better efficacy than PPA towards the tumor cell lines mentioned. Compound <b>6</b> was potent against six cancer cell lines, HCT-116, PC-3, K562, NCI-H929, Jurkat, and RPMI8226, showing a 47, 13.5, 16, 4, 1. ...[more]

PMID: 30469343

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