Ontology highlight
ABSTRACT:
SUBMITTER: Hossion AM
PROVIDER: S-EPMC4027153 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Hossion Abugafar M L AM Bio Moses M Nkepang Gregory G Awuah Samuel G SG You Youngjae Y
ACS medicinal chemistry letters 20121121 1
We designed and synthesized a novel double activatable prodrug system (drug-linker-deactivated photosensitizer), containing a photocleavable aminoacrylate-linker and a deactivated photosensitizer, to achieve the spatiotemporally controlled release of parent drugs using visible light. Three prodrugs of CA-4, SN-38, and coumarin were prepared to demonstrate the activation of deactivated photosensitizer by cellular esterase and the release of parent drugs by visible light (540 nm) via photounclick ...[more]