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Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system.

ABSTRACT: We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules. Release is mediated by a novel class of photochromic material - donor-acceptor Stenhouse adducts (DASAs). We demonstrate controlled delivery of small molecules such as the chemotherapeutic agent (paclitaxel) to human breast cancer cells triggered by micellar switching with low intensity, visible light.

SUBMITTER: Poelma SO

PROVIDER: S-EPMC5015652 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system.

Poelma Saemi O SO Oh Seung Soo SS Helmy Sameh S Knight Abigail S AS Burnett G Leslie GL Soh H Tom HT Hawker Craig J CJ Read de Alaniz Javier J

Chemical communications (Cambridge, England) 20160801 69

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules. Release is mediated by a novel class of photochromic material - donor-acceptor Stenhouse adducts (DASAs). We demonstrate controlled delivery of small molecules such as the chemotherapeutic agent (paclitaxel) to human breast cancer cells triggered by micellar switching with low intensity, visible light. ...[more]

PMID: 27491357

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