Ontology highlight
ABSTRACT:
SUBMITTER: Lagana A
PROVIDER: S-EPMC4027198 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Nucleic acids research 20140313 9
RNAi is a powerful tool for the regulation of gene expression. It is widely and successfully employed in functional studies and is now emerging as a promising therapeutic approach. Several RNAi-based clinical trials suggest encouraging results in the treatment of a variety of diseases, including cancer. Here we present miR-Synth, a computational resource for the design of synthetic microRNAs able to target multiple genes in multiple sites. The proposed strategy constitutes a valid alternative to ...[more]