Tuning RNA Interference by Enhancing siRNA/PAZ Recognition.
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ABSTRACT:
SUBMITTER: Gaglione M
PROVIDER: S-EPMC4027432 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition.
Gaglione Maria M Potenza Nicoletta N Di Fabio Giovanni G Romanucci Valeria V Mosca Nicola N Russo Aniello A Novellino Ettore E Cosconati Sandro S Messere Anna A
ACS medicinal chemistry letters 20121116 1
Chemically modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theoretical data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ. ...[more]
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