Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5866582 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Li Jiahe J Wu Connie C Wang Wade W He Yanpu Y Elkayam Elad E Joshua-Tor Leemor L Hammond Paula T PT
Proceedings of the National Academy of Sciences of the United States of America 20180205 12
Small interfering RNA (siRNA) represents a promising class of inhibitors in both fundamental research and the clinic. Numerous delivery vehicles have been developed to facilitate siRNA delivery. Nevertheless, achieving highly potent RNA interference (RNAi) toward clinical translation requires efficient formation of RNA-induced gene-silencing complex (RISC) in the cytoplasm. Here we coencapsulate siRNA and the central RNAi effector protein Argonaute 2 (Ago2) via different delivery carriers as a p ...[more]