Ontology highlight
ABSTRACT:
SUBMITTER: Martelli A
PROVIDER: S-EPMC4027465 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Martelli Alma A Testai Lara L Citi Valentina V Marino Alice A Pugliesi Isabella I Barresi Elisabetta E Nesi Giulia G Rapposelli Simona S Taliani Sabrina S Da Settimo Federico F Breschi Maria C MC Calderone Vincenzo V
ACS medicinal chemistry letters 20130808 10
A small library of arylthioamides 1-12 was easily synthesized, and their H2S-releasing properties were evaluated both in the absence or in the presence of an organic thiol such as l-cysteine. A number of arylthioamides (1-3 and 7) showed a slow and l-cysteine-dependent H2S-releasing mechanism, similar to that exhibited by the reference slow H2S-releasing agents, such as diallyl disulfide (DADS) and the phosphinodithioate derivative GYY 4137. Compound 1 strongly abolished the noradrenaline-induce ...[more]