Dataset Information

Cysteine-activated hydrogen sulfide (H2S) donors.

ABSTRACT: H(2)S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H(2)S has been hindered by the lack of controllable H(2)S donors that could mimic the slow and continuous H(2)S generation process in vivo. Herein we report a series of cysteine-activated H(2)S donors. Structural modifications of these molecules can regulate the rates of H(2)S generation. These compounds can be useful tools in H(2)S research.

SUBMITTER: Zhao Y

PROVIDER: S-EPMC3073703 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Cysteine-activated hydrogen sulfide (H2S) donors.

Zhao Yu Y Wang Hua H Xian Ming M

Journal of the American Chemical Society 20101210 1

H(2)S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H(2)S has been hindered by the lack of controllable H(2)S donors that could mimic the slow and continuous H(2)S generation process in vivo. Herein we report a series of cysteine-activated H(2)S donors. Structural modifications of these molecules can regulate the rates of H(2)S generation. These compounds can be useful tools in H(2)S research. ...[more]

PMID: 21142018

Similar Datasets

Project description:As one of the three mammalian gasotransmitters, hydrogen sulfide (H2S) plays a major role in maintaining physiological homeostasis. Endogenously produced H2S plays numerous beneficial roles including mediating vasodilation and conferring neuroprotection. Due to its high membrane permeability, exogenously produced H2S originating from the gut microbiota can also influence human physiology and is implicated in reducing intestinal mucosal integrity and potentiating genotoxicity and is therefore a potential target for therapeutic interventions. Gut microbial H2S production is often attributed to dissimilatory sulfate reducers such as Desulfovibrio and Bilophila species. However, an alternative source for H2S production, cysteine degradation, is present in some gut microbes, but the genes responsible for cysteine degradation have not been systematically annotated in all known gut microbes. We classify mechanisms of cysteine degradation into primary, secondary, and erroneous levels of H2S production and perform a comprehensive search for primary, secondary, and erroneous cysteine-degrading enzymes in 4,644 non-redundant bacterial genomes from the Unified Human Gastrointestinal Genome (UHGG) catalog. Of the 4,644 genomes we have putatively identified 2,046 primary, 1,951 secondary, and 5 erroneous cysteine-degrading species. We identified the presence of at least one putative cysteine-degrading bacteria in metagenomic data of 100% of 6,623 healthy subjects and the expression of cysteine-degrading genes in metatranscriptomic data of 100% of 736 samples taken from 318 individuals. Additionally, putative cysteine-degrading bacteria are more abundant than sulfate-reducing bacteria across healthy controls, IBD patients and CRC patients (p < 2.2e-16, Wilcoxon rank sum test). Although we have linked many taxa with the potential for cysteine degradation, experimental validation is required to establish the H2S production potential of the gut microbiome. Overall, this study improves our understanding of the capacity for H2S production by the human gut microbiome and may help to inform interventions to therapeutically modulate gut microbial H2S production.

Dataset Information

Cysteine-activated hydrogen sulfide (H2S) donors.

Publications

Cysteine-activated hydrogen sulfide (H2S) donors.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets