Ontology highlight
ABSTRACT:
SUBMITTER: Ochoa-Puentes C
PROVIDER: S-EPMC4027546 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20130304 4
Recently reported compounds such as UR-COP78 (6) are among the most potent and selective ABCG2 modulators known so far but are prone to rapid enzymatic cleavage at the central benzanilide moiety. In search for more stable analogues, according to a bioisosteric approach, a series of N-(biphenyl-3-yl)quinoline carboxamides was prepared by solid phase and solution phase synthesis. The biphenyl moiety was constructed by Suzuki coupling. Inhibition of ABCB1 and ABCG2 was determined in a calcein-AM an ...[more]