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Expansion of Antibacterial Spectrum of Muraymycins toward Pseudomonas aeruginosa.


ABSTRACT: It is urgent to develop novel anti-Pseudomonas agents that should also be active against multidrug resistant P. aeruginosa. Expanding the antibacterial spectrum of muraymycins toward P. aeruginosa was investigated by the systematic structure-activity relationship study. It was revealed that two functional groups, a lipophilic side chain and a guanidino group, at the accessory moiety of muraymycins were important for the anti-Pseudomonas activity, and analogue 29 exhibited antibacterial activity against a range of P. aeruginosa strains with the minimum inhibitory concentration values of 4-8 ?g/mL.

SUBMITTER: Takeoka Y 

PROVIDER: S-EPMC4027578 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Expansion of Antibacterial Spectrum of Muraymycins toward Pseudomonas aeruginosa.

Takeoka Yusuke Y   Tanino Tetsuya T   Sekiguchi Mitsuaki M   Yonezawa Shuji S   Sakagami Masahiro M   Takahashi Fumiyo F   Togame Hiroko H   Tanaka Yoshikazu Y   Takemoto Hiroshi H   Ichikawa Satoshi S   Matsuda Akira A  

ACS medicinal chemistry letters 20140306 5


It is urgent to develop novel anti-Pseudomonas agents that should also be active against multidrug resistant P. aeruginosa. Expanding the antibacterial spectrum of muraymycins toward P. aeruginosa was investigated by the systematic structure-activity relationship study. It was revealed that two functional groups, a lipophilic side chain and a guanidino group, at the accessory moiety of muraymycins were important for the anti-Pseudomonas activity, and analogue 29 exhibited antibacterial activity  ...[more]

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