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ABSTRACT:
SUBMITTER: Takeoka Y
PROVIDER: S-EPMC4027578 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Takeoka Yusuke Y Tanino Tetsuya T Sekiguchi Mitsuaki M Yonezawa Shuji S Sakagami Masahiro M Takahashi Fumiyo F Togame Hiroko H Tanaka Yoshikazu Y Takemoto Hiroshi H Ichikawa Satoshi S Matsuda Akira A
ACS medicinal chemistry letters 20140306 5
It is urgent to develop novel anti-Pseudomonas agents that should also be active against multidrug resistant P. aeruginosa. Expanding the antibacterial spectrum of muraymycins toward P. aeruginosa was investigated by the systematic structure-activity relationship study. It was revealed that two functional groups, a lipophilic side chain and a guanidino group, at the accessory moiety of muraymycins were important for the anti-Pseudomonas activity, and analogue 29 exhibited antibacterial activity ...[more]