Potent Hepatitis C Virus NS5A Inhibitors Containing a Benzidine Core.
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ABSTRACT:
SUBMITTER: Bae IH
PROVIDER: S-EPMC4027583 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Potent Hepatitis C Virus NS5A Inhibitors Containing a Benzidine Core.
Bae Il Hak IH Choi Jin Kyu JK Chough Chieyeon C Keum Sun Ju SJ Kim Heesun H Jang Sung Key SK Kim B Moon BM
ACS medicinal chemistry letters 20131204 3
Here we report the discovery of a series of potent hepatitis C virus (HCV) NS5A inhibitors based on the benzidine prolinamide backbone. Taking a simple synthetic route, we developed a novel inhibitor structure, which allows easy modification, and through optimization of the capping group, we identified compound 6 with highly potent anti-HCV activity. Compound 6 is nontoxic and is anticipated to be an effective HCV drug candidate. ...[more]
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