Ontology highlight
ABSTRACT:
SUBMITTER: Asante-Appiah E
PROVIDER: S-EPMC6201069 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Asante-Appiah Ernest E Liu Rong R Curry Stephanie S McMonagle Patricia P Agrawal Sony S Carr Donna D Rokosz Laura L Lahser Frederick F Bystol Karin K Chase Robert R Black Stuart S Ferrari Eric E Ingravallo Paul P Tong Ling L Yu Wensheng W Kozlowski Joseph J
Antimicrobial agents and chemotherapy 20181024 11
Inhibition of NS5A has emerged as an attractive strategy to intervene in hepatitis C virus (HCV) replication. Ruzasvir (formerly MK-8408) was developed as a novel NS5A inhibitor to improve upon the potency and barrier to resistance of early compounds. Ruzasvir inhibited HCV RNA replication with 50% effective concentrations (EC<sub>50</sub>s) of 1 to 4 pM in Huh7 or Huh7.5 cells bearing replicons for HCV genotype 1 (GT1) to GT7. The antiviral activity was modestly (10-fold) reduced in the presenc ...[more]