Discovery of Short Peptides Exhibiting High Potency against Cryptococcus neoformans.
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ABSTRACT:
SUBMITTER: Mahindra A
PROVIDER: S-EPMC4027598 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Discovery of Short Peptides Exhibiting High Potency against Cryptococcus neoformans.
Mahindra Amit A Bagra Nitin N Wangoo Nishima N Khan Shabana I SI Jacob Melissa R MR Jain Rahul R
ACS medicinal chemistry letters 20140115 4
Rapid increase in the emergence of resistance against existing antifungal drugs created a need to discover new structural classes of antifungal agents. In this study we describe the synthesis of a new structural class of short antifungal peptidomimetcis, their activity, and plausible mechanism of action. The results of the study show that peptides 11e and 11f are more potent than the control drug amphotericin B, with no cytotoxicity to human cancer cells and noncancerous mammalian kidney cells. ...[more]
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