Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans.
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ABSTRACT:
SUBMITTER: Corson AE
PROVIDER: S-EPMC5150681 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Discovery and Characterization of a Peptoid with Antifungal Activity against <i>Cryptococcus neoformans</i>.
Corson Ashley E AE Armstrong Scott A SA Wright Matthew E ME McClelland Erin E EE Bicker Kevin L KL
ACS medicinal chemistry letters 20161003 12
Studies show there is an increasing rate of fungal infections, especially in immunocompromised patients and treatments for fungal genera, such as <i>Aspergillus</i>, <i>Candida</i>, and <i>Cryptococcus</i>, carry significant cytotoxicity with an increasing prevalence of antifungal resistance. We have previously reported a high-throughput assay for identifying peptoids with antimicrobial properties from combinatorial libraries. Here we report the application of this assay in identifying a peptoid ...[more]
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