Ontology highlight
ABSTRACT:
SUBMITTER: Fujii H
PROVIDER: S-EPMC4027615 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20140127 4
We synthesized compounds 4a,c-f,h,i containing the oxazatricyclodecane structure from a novel rearrangement reaction product 2a. All the prepared compounds 4a,c-f,h,i exhibited full agonistic activities for the δ opioid receptor (DOR). Among them, the N-methyl derivative 4c was highly selective, and the most effective DOR agonist in functional assays. Subcutaneous administration of 4c produced dose-dependent and NTI (selective DOR antagonist)-reversible antinociception lacking any convulsive beh ...[more]