Ontology highlight
ABSTRACT:
SUBMITTER: Claff T
PROVIDER: S-EPMC6881160 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Science advances 20191127 11
Selective activation of the δ-opioid receptor (DOP) has great potential for the treatment of chronic pain, benefitting from ancillary anxiolytic and antidepressant-like effects. Moreover, DOP agonists show reduced adverse effects as compared to μ-opioid receptor (MOP) agonists that are in the spotlight of the current "opioid crisis." Here, we report the first crystal structures of the DOP in an activated state, in complex with two relevant and structurally diverse agonists: the potent opioid ago ...[more]