Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes.
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ABSTRACT:
SUBMITTER: Matimba A
PROVIDER: S-EPMC4027966 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes.
Matimba Alice A Li Fang F Livshits Alina A Cartwright Cher S CS Scully Stephen S Fridley Brooke L BL Jenkins Gregory G Batzler Anthony A Wang Liewei L Weinshilboum Richard R Lennard Lynne L
Pharmacogenomics 20140301 4
<h4>Aim</h4>We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia.<h4>Materials & methods</h4>We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine cytotoxicity using lymphoblastoid cell lines. We then genotyped the top SNPs associated with lymphoblastoid cell line cytotoxicity, together with tagSNPs for genes in the 'thiopurine pathway' (686 total SNPs), in DNA from 589 Caucasian UK ...[more]
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