Ontology highlight
ABSTRACT:
SUBMITTER: Daly AK
PROVIDER: S-EPMC5872075 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Daly Ann K AK Rettie Allan E AE Fowler Douglas M DM Miners John O JO
Journal of personalized medicine 20171228 1
CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most important contributor from this subfamily to drug metabolism. Polymorphisms resulting in decreased enzyme activity are common in the <i>CYP2C9</i> gene and this, combined with narrow therapeutic indices for several key drug substrates, results in some important issues relating to drug safety and efficacy. CYP2C9 substrate selectivity is detailed and, based on crystal structures for the enzyme, we describe how CYP2C9 c ...[more]