Ontology highlight
ABSTRACT:
SUBMITTER: Ochiai K
PROVIDER: S-EPMC4028049 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Ochiai Kyoko K Maienschein-Cline Mark M Mandal Malay M Triggs Joseph R JR Bertolino Eric E Sciammas Roger R Dinner Aaron R AR Clark Marcus R MR Singh Harinder H
Nature immunology 20120122 3
The molecular crosstalk between the interleukin 7 receptor (IL-7R) and the precursor to the B cell antigen receptor (pre-BCR) in B lymphopoiesis has not been elucidated. Here we demonstrate that in pre-B cells, the IL-7R but not the pre-BCR was coupled to phosphatidylinositol-3-OH kinase (PI(3)K) and the kinase Akt; signaling by this pathway inhibited expression of recombination-activating gene 1 (Rag1) and Rag2. Attenuation of IL-7 signaling resulted in upregulation of the transcription factors ...[more]