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A role for IL-27 in limiting T regulatory cell populations.

ABSTRACT: IL-27 is a cytokine that regulates Th function during autoimmune and pathogen-induced immune responses. Although previous studies have shown that regulatory T cells (Tregs) express the IL-27R, and that IL-27 inhibits forkhead box P3 upregulation in vitro, little is known about how IL-27 influences Tregs in vivo. The studies presented in this article show that mice that overexpress IL-27 had decreased Treg frequencies and developed spontaneous inflammation. Although IL-27 did not cause mature Tregs to downregulate forkhead box P3, transgenic overexpression in vivo limited the size of a differentiating Treg population in a bone marrow chimera model, which correlated with reduced production of IL-2, a vital cytokine for Treg maintenance. These data identify an indirect role for IL-27 in shaping the Treg pool.

SUBMITTER: Wojno ED

PROVIDER: S-EPMC3119737 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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A role for IL-27 in limiting T regulatory cell populations.

Wojno Elia D Tait ED Hosken Nancy N Stumhofer Jason S JS O'Hara Aisling C AC Mauldin Elizabeth E Fang Qun Q Turka Laurence A LA Levin Steven D SD Hunter Christopher A CA

Journal of immunology (Baltimore, Md. : 1950) 20110527 1

IL-27 is a cytokine that regulates Th function during autoimmune and pathogen-induced immune responses. Although previous studies have shown that regulatory T cells (Tregs) express the IL-27R, and that IL-27 inhibits forkhead box P3 upregulation in vitro, little is known about how IL-27 influences Tregs in vivo. The studies presented in this article show that mice that overexpress IL-27 had decreased Treg frequencies and developed spontaneous inflammation. Although IL-27 did not cause mature Tre ...[more]

PMID: 21622862

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