Ontology highlight
ABSTRACT:
SUBMITTER: Duncan KK
PROVIDER: S-EPMC4029506 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20140318 9
A series of α-ketooxazoles containing heteroatoms embedded within conformational constraints in the C2 acyl side chain of 2 (OL-135) were synthesized and evaluated as inhibitors of fatty acid amide hydrolase (FAAH). The studies reveal that the installation of a heteroatom (O) in the conformational constraint is achievable, although the potency of these novel derivatives is reduced slightly relative to 2 and the analogous 1,2,3,4-tetrahydronaphthalene series. Interestingly, both enantiomers (R an ...[more]