Ontology highlight
ABSTRACT:
SUBMITTER: Won CS
PROVIDER: S-EPMC4029847 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Won Christina S CS Lan Tian T Vandermolen Karen M KM Dawson Paul A PA Oberlies Nicholas H NH Widmer Wilbur W WW Scarlett Yolanda V YV Paine Mary F MF
Journal of clinical pharmacology 20130723 9
The grapefruit juice (GFJ)-fexofenadine interaction involves inhibition of intestinal organic anion transporting polypeptide (OATP)-mediated uptake. Only naringin has been shown clinically to inhibit intestinal OATP; other constituents have not been evaluated. The effects of a modified GFJ devoid of furanocoumarins (~99%) and polymethoxyflavones (~90%) on fexofenadine disposition were compared to effects of the original juice. Extracts of both juices inhibited estrone 3-sulfate and fexofenadine ...[more]