Ontology highlight
ABSTRACT:
SUBMITTER: Booth DG
PROVIDER: S-EPMC4032110 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Booth Daniel G DG Takagi Masatoshi M Sanchez-Pulido Luis L Petfalski Elizabeth E Vargiu Giulia G Samejima Kumiko K Imamoto Naoko N Ponting Chris P CP Tollervey David D Earnshaw William C WC Vagnarelli Paola P
eLife 20140527
When the nucleolus disassembles during open mitosis, many nucleolar proteins and RNAs associate with chromosomes, establishing a perichromosomal compartment coating the chromosome periphery. At present nothing is known about the function of this poorly characterised compartment. In this study, we report that the nucleolar protein Ki-67 is required for the assembly of the perichromosomal compartment in human cells. Ki-67 is a cell-cycle regulated protein phosphatase 1-binding protein that is invo ...[more]