Ontology highlight
ABSTRACT:
SUBMITTER: Zou Q
PROVIDER: S-EPMC4032322 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Zou Qiang Q Jin Jin J Hu Hongbo H Li Haiyan S HS Romano Simona S Xiao Yichuan Y Nakaya Mako M Zhou Xiaofei X Cheng Xuhong X Yang Peirong P Lozano Guillermina G Zhu Chengming C Watowich Stephanie S SS Ullrich Stephen E SE Sun Shao-Cong SC
Nature immunology 20140428 6
Deubiquitinases (DUBs) are a new class of drug targets, although the physiological function of only few DUBs has been characterized. Here we identified the DUB USP15 as a crucial negative regulator of T cell activation. USP15 stabilized the E3 ubiquitin ligase MDM2, which in turn negatively regulated T cell activation by targeting the degradation of the transcription factor NFATc2. USP15 deficiency promoted T cell activation in vitro and enhanced T cell responses to bacterial infection and tumor ...[more]