Ontology highlight
ABSTRACT:
SUBMITTER: Meng L
PROVIDER: S-EPMC5048913 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Meng Lingjun L Lin Tao T Tsai Robert Y L RY
Journal of cell science 20081125 Pt 24
Nucleolar disassembly occurs during mitosis and nucleolar stress, releasing several MDM2-interactive proteins residing in the nucleolus that share the common activity of p53 stabilization. Here, we demonstrate that mobilization of nucleostemin, a nucleolar protein enriched in cancer and stem cells, has the opposite role of stabilizing MDM2 and suppressing p53 functions. Our results show that nucleostemin increases the protein stability and nucleoplasmic retention of MDM2, and competes with L23 f ...[more]