Ontology highlight
ABSTRACT:
SUBMITTER: Shimizu H
PROVIDER: S-EPMC4032575 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Shimizu Hideyuki H Woodcock Simon A SA Wilkin Marian B MB Trubenová Barbora B Monk Nicholas A M NA Baron Martin M
Cell 20140501 5
Developmental signaling is remarkably robust to environmental variation, including temperature. For example, in ectothermic animals such as Drosophila, Notch signaling is maintained within functional limits across a wide temperature range. We combine experimental and computational approaches to show that temperature compensation of Notch signaling is achieved by an unexpected variety of endocytic-dependent routes to Notch activation which, when superimposed on ligand-induced activation, act as a ...[more]