KIBRA: In the brain and beyond.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC4032603 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
KIBRA: In the brain and beyond.
Zhang Lin L Yang Shuping S Wennmann Dirk Oliver DO Chen Yuanhong Y Kremerskothen Joachim J Dong Jixin J
Cellular signalling 20140315 7
In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the bioche ...[more]
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