Ontology highlight
ABSTRACT:
SUBMITTER: Duning K
PROVIDER: S-EPMC2551571 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Duning Kerstin K Schurek Eva-Maria EM Schlüter Marc M Bayer Michael M Reinhardt Hans-Christian HC Schwab Albrecht A Schaefer Liliana L Benzing Thomas T Schermer Bernhard B Saleem Moin A MA Huber Tobias B TB Bachmann Sebastian S Kremerskothen Joachim J Weide Thomas T Pavenstädt Hermann H
Journal of the American Society of Nephrology : JASN 20080702 10
Asymmetric delivery and distribution of macromolecules are essential for cell polarity and for cellular functions such as differentiation, division, and signaling. Injury of podocytes, which are polarized epithelial cells, changes the dynamics of the actin meshwork, resulting in foot process retraction and proteinuria. Although the spatiotemporal control of specific protein-protein interactions is crucial for the establishment of cell polarity, the mechanisms controlling polarity-dependent diffe ...[more]