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Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle.

ABSTRACT: Mitotic cell division is the most fundamental task of all living cells. Cells have intricate and tightly regulated machinery to ensure that mitosis occurs with appropriate frequency and high fidelity. A core element of this machinery is the kinesin-5 motor protein, which plays essential roles in spindle formation and maintenance. In this review, we discuss how the structural and mechanical properties of kinesin-5 motors uniquely suit them to their mitotic role. We describe some of the small molecule inhibitors and regulatory proteins that act on kinesin-5, and discuss how these regulators may influence the process of cell division. Finally, we touch on some more recently described functions of kinesin-5 motors in non-dividing cells. Throughout, we highlight a number of open questions that impede our understanding of both this motor's function and the potential utility of kinesin-5 inhibitors.

SUBMITTER: Waitzman JS

PROVIDER: S-EPMC4034379 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle.

Waitzman Joshua S JS Rice Sarah E SE

Biology of the cell 20131126 1

Mitotic cell division is the most fundamental task of all living cells. Cells have intricate and tightly regulated machinery to ensure that mitosis occurs with appropriate frequency and high fidelity. A core element of this machinery is the kinesin-5 motor protein, which plays essential roles in spindle formation and maintenance. In this review, we discuss how the structural and mechanical properties of kinesin-5 motors uniquely suit them to their mitotic role. We describe some of the small mole ...[more]

PMID: 24125467

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