Ontology highlight
ABSTRACT:
SUBMITTER: Xia P
PROVIDER: S-EPMC4034728 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Xia Peng P Zhou Jinhua J Song Xiaoyu X Wu Bing B Liu Xing X Li Di D Zhang Shuyuan S Wang Zhikai Z Yu Huijuan H Ward Tarsha T Zhang Jiancun J Li Yinmei Y Wang Xiaoning X Chen Yong Y Guo Zhen Z Yao Xuebiao X
Journal of molecular cell biology 20140520 3
Entosis, a cell-in-cell process, has been implicated in the formation of aneuploidy associated with an aberrant cell division control. Microtubule plus-end-tracking protein TIP150 facilitates the loading of MCAK onto the microtubule plus ends and orchestrates microtubule plus-end dynamics during cell division. Here we show that TIP150 cooperates with MCAK to govern entosis via a regulatory circuitry that involves Aurora A-mediated phosphorylation of MCAK. Our biochemical analyses show that MCAK ...[more]