Ontology highlight
ABSTRACT:
SUBMITTER: Nowak JS
PROVIDER: S-EPMC4035284 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Nowak Jakub S JS Choudhury Nila Roy NR de Lima Alves Flavia F Rappsilber Juri J Michlewski Gracjan G
Nature communications 20140411
microRNAs shape the identity and function of cells by regulating gene expression. It is known that brain-specific miR-9 is controlled transcriptionally; however, it is unknown whether post-transcriptional processes contribute to establishing its levels. Here we show that miR-9 is regulated transcriptionally and post-transcriptionally during neuronal differentiation of the embryonic carcinoma cell line P19. We demonstrate that miR-9 is more efficiently processed in differentiated than in undiffer ...[more]