Ontology highlight
ABSTRACT:
SUBMITTER: Chaudhuri AA
PROVIDER: S-EPMC3306721 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Chaudhuri Aadel A AA So Alex Yick-Lun AY Mehta Arnav A Minisandram Aarathi A Sinha Nikita N Jonsson Vanessa D VD Rao Dinesh S DS O'Connell Ryan M RM Baltimore David D
Proceedings of the National Academy of Sciences of the United States of America 20120224 11
MicroRNA-125b (miR-125b) is up-regulated in patients with leukemia. Overexpression of miR-125b alone in mice causes a very aggressive, transplantable myeloid leukemia. Before leukemia, these mice do not display elevation of white blood cells in the spleen or bone marrow; rather, the hematopoietic compartment shows lineage-skewing, with myeloid cell numbers dramatically increased and B-cell numbers severely diminished. miR-125b exerts this effect by up-regulating the number of common myeloid prog ...[more]