Ontology highlight
ABSTRACT:
SUBMITTER: Likhtik E
PROVIDER: S-EPMC4035371 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Likhtik Ekaterina E Stujenske Joseph M JM Topiwala Mihir A MA Harris Alexander Z AZ Gordon Joshua A JA
Nature neuroscience 20131117 1
Successfully differentiating safety from danger is an essential skill for survival. While decreased activity in the medial prefrontal cortex (mPFC) is associated with fear generalization in animals and humans, the circuit-level mechanisms used by the mPFC to discern safety are not clear. To answer this question, we recorded activity in the mPFC, basolateral amygdala (BLA) and dorsal and ventral hippocampus in mice during exposure to learned (differential fear conditioning) and innate (open field ...[more]