Ontology highlight
ABSTRACT:
SUBMITTER: Tien DN
PROVIDER: S-EPMC4035583 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Scientific reports 20140528
NF-κB is a major transcriptional factor regulating many cellular functions including inflammation; therefore, its appropriate control is of high importance. The detailed mechanism of its activation has been well characterized, but that of negative regulation is poorly understood. In this study, we showed AMAP1, an Arf-GTPase activating protein, as a negative feedback regulator for NF-κB by binding with IKKβ, an essential kinase in NF-κB signaling. Proteomics analysis identified AMAP1 as a bindin ...[more]