Association between risk of oral precancer and genetic variations in microRNA and related processing genes.
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ABSTRACT:
SUBMITTER: Roy R
PROVIDER: S-EPMC4035900 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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Association between risk of oral precancer and genetic variations in microRNA and related processing genes.
Roy Roshni R De Sarkar Navonil N Ghose Sandip S Paul Ranjan R RR Ray Anindita A Mukhopadhyay Indranil I Roy Bidyut B
Journal of biomedical science 20140517
<h4>Background</h4>MicroRNAs have been implicated in cancer but studies on their role in precancer, such as leukoplakia, are limited. Sequence variations at eight miRNA and four miRNA processing genes were studied in 452 healthy controls and 299 leukoplakia patients to estimate risk of disease.<h4>Results</h4>Genotyping by TaqMan assay followed by statistical analyses showed that variant genotypes at Gemin3 and mir-34b reduced risk of disease [OR = 0.5(0.3-0.9) and OR = 0.7(0.5-0.9) respectively ...[more]
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