Ontology highlight
ABSTRACT:
SUBMITTER: Stopczynski RE
PROVIDER: S-EPMC4036226 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Stopczynski Rachelle E RE Normolle Daniel P DP Hartman Douglas J DJ Ying Haoqiang H DeBerry Jennifer J JJ Bielefeldt Klaus K Rhim Andrew D AD DePinho Ronald A RA Albers Kathryn M KM Davis Brian M BM
Cancer research 20140121 6
Perineural tumor invasion of intrapancreatic nerves, neurogenic inflammation, and tumor metastases along extrapancreatic nerves are key features of pancreatic malignancies. Animal studies show that chronic pancreatic inflammation produces hypertrophy and hypersensitivity of pancreatic afferents and that sensory fibers may themselves drive inflammation via neurogenic mechanisms. Although genetic mutations are required for cancer development, inflammation has been shown to be a precipitating event ...[more]