Ontology highlight
ABSTRACT:
SUBMITTER: Salaymeh Y
PROVIDER: S-EPMC7156281 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Salaymeh Yaser Y Farago Marganit M Sebban Shulamit S Shalom Batel B Pikarsky Eli E Katzav Shulamit S
Life science alliance 20200410 5
To explore the contribution of Vav1, a hematopoietic signal transducer, to pancreatic ductal adenocarcinoma (PDAC) development, we generated transgenic mouse lines expressing, Vav1, K-Ras<sup>G12D</sup>, or both K-Ras<sup>G12D</sup> and Vav1 in pancreatic acinar cells. Co-expression of Vav1 and K-Ras<sup>G12D</sup> synergistically enhanced acinar-to-ductal metaplasia (ADM) formation, far exceeding the number of lesions developed in K-Ras<sup>G12D</sup> mice. Mice expressing only Vav1 did not dev ...[more]