Ontology highlight
ABSTRACT:
SUBMITTER: Kolesnikoff N
PROVIDER: S-EPMC4036258 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Kolesnikoff Natasha N Attema Joanne L JL Roslan Suraya S Bert Andrew G AG Schwarz Quenten P QP Gregory Philip A PA Goodall Gregory J GJ
The Journal of biological chemistry 20140313 16
Epithelial-mesenchymal transition (EMT) is required for the specification of tissues during embryonic development and is recapitulated during the metastatic progression of tumors. The miR-200 family plays a critical role in enforcing the epithelial state with their expression lost in cells undergoing EMT. EMT can be mediated by activation of the ZEB1 and ZEB2 (ZEB) transcription factors, which repress miR-200 expression via a self-reinforcing double negative feedback loop to promote the mesenchy ...[more]