Ontology highlight
ABSTRACT:
SUBMITTER: Haraguchi T
PROVIDER: S-EPMC4758077 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Haraguchi Takeshi T Kondo Masayuki M Uchikawa Ryo R Kobayashi Kazuyoshi K Hiramatsu Hiroaki H Kobayashi Kyousuke K Chit Ung Weng UW Shimizu Takanobu T Iba Hideo H
Scientific reports 20160218
Whereas miR-200 family is known to be involved in the epithelial-to-mesenchymal transition (EMT), a crucial biological process observed in normal and pathological contexts, it has been largely unclear how far the functional levels of these tiny RNAs alone can propagate the molecular events to accomplish this process within several days. By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, w ...[more]