Ontology highlight
ABSTRACT:
SUBMITTER: Belmont PJ
PROVIDER: S-EPMC4036469 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Belmont Peter J PJ Budinska Eva E Jiang Ping P Sinnamon Mark J MJ Coffee Erin E Roper Jatin J Xie Tao T Rejto Paul A PA Derkits Sahra S Sansom Owen J OJ Delorenzi Mauro M Tejpar Sabine S Hung Kenneth E KE Martin Eric S ES
Disease models & mechanisms 20140417 6
Effective treatment options for advanced colorectal cancer (CRC) are limited, survival rates are poor and this disease continues to be a leading cause of cancer-related deaths worldwide. Despite being a highly heterogeneous disease, a large subset of individuals with sporadic CRC typically harbor relatively few established 'driver' lesions. Here, we describe a collection of genetically engineered mouse models (GEMMs) of sporadic CRC that combine lesions frequently altered in human patients, incl ...[more]