Dataset Information
Expression data from genetically engineered mouse models (GEMMs)
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Peter Belmont
PROVIDER: E-GEOD-39557 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
Clinical cancer research : an official journal of the American Association for Cancer Research 20130212 11
<h4>Purpose</h4>Effective therapies for KRAS-mutant colorectal cancer (CRC) are a critical unmet clinical need. Previously, we described genetically engineered mouse models (GEMM) for sporadic Kras-mutant and non-mutant CRC suitable for preclinical evaluation of experimental therapeutics. To accelerate drug discovery and validation, we sought to derive low-passage cell lines from GEMM Kras-mutant and wild-type tumors for in vitro screening and transplantation into the native colonic environment ...[more]
